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Fig. 3 | Burns & Trauma

Fig. 3

From: Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

Fig. 3

Inhibition of TGF-β1 or ERK1/2 signaling inhibits migration of keloid keratinocytes. a An in vitro wound healing assay was performed to measure the effects of inhibitors of TGF-β1 signaling (SB525334) or ERK1/2 signaling (U0126) on migration of keloid keratinocytes (N = 4 donor strains). Representative images of wound healing assay are shown. b Quantitative analysis of the in vitro wound healing assay. Mean values for four donor strains (+ standard deviations) are plotted vs. time (hours). Statistically significant differences at specific time points are indicated by symbols: *p < 0.001 control vs. both other groups; $ p < 0.001 control vs. SB525334; # p < 0.02 control vs. U0126; @ p < 0.05 SB525334 vs. U0126

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Burns & Trauma

ISSN: 2321-3876

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