Skip to main content
Fig. 2 | Burns & Trauma

Fig. 2

From: Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

Fig. 2

Inhibition of ERK1/2 and p38 MAPK signaling in keloid keratinocytes alters TGF-β1-induced gene expression. Keloid keratinocytes (four donor strains) were pre-incubated with inhibitors of ERK1/2 signaling (U0126) or p38 MAPK signaling (SB203580), prior to treatment with TGF-β1. Gene expression levels, quantified by qPCR, are shown for HAS2 (a), VIM (b), CDH11 (c), WNT5A (d), ADAM19 (e), and IL6 (f). White bars, no treatment; black bars, +TGF-β1; red bars, +U0126; yellow bars, +U0126 + TGF-β1; blue bars, +SB203580; green bars, +SB203580 + TGF-β1. Statistically significant differences are indicated by symbols: *p < 0.001; @ p < 0.01; # p < 0.05

Back to article page